Chapter 1: Life (Genome)

The word is described as proselytizing the sea, rearranging chemicals to create life, and transforming the planet into a verdant paradise. The author also notes the significance of being alive at this point in Earth’s history and the privilege of being born as a human being and in the country where the structure of DNA was discovered. The author expresses enthusiasm for this discovery and hopes to convince the reader of its immense fascination.

Ridley explains that the filament of DNA is a code of chemicals that is written in a linear and digital language with an alphabet of only four letters (A, C, G, and T). He notes that the idea that genes are coded recipes was not widely accepted before the discovery of DNA’s symmetrical structure in 1953. The author then goes on to mention that some of the key figures in the discovery of the structure of DNA were working on other things in 1943, such as Francis Crick working on naval mines and James Watson studying ornithology.

Ridley discussed the efforts of various scientists to understand the nature of heredity and the secret of life in the year 1943. He mentions that Josef Mengele in Auschwitz is using grotesque methods to understand heredity, but his results will be useless. He also mentions Erwin Schrodinger, a physicist, who is giving lectures on the topic in Dublin but is unable to understand how chromosomes contain the secret of life. The passage also mentions Oswald Avery, a Canadian scientist, who is putting the finishing touches to an experiment that will identify DNA as the chemical manifestation of heredity. He has conducted a series of experiments that shows a pneumonia bacterium can be transformed from a harmless to a virulent strain merely by absorbing a simple chemical solution. But he will couch his conclusions in such cautious language for publication that few will take notice until much later.

Scientists are trying to understand the nature of heredity and the secret of life, Ridley focuses on the work of Oswald Avery and his experiments with DNA. He states that Avery is almost there in understanding the mystery of life, but he is still thinking in chemical lines and that the answer will not come from chemistry. He also mentions the work of Alan Turing, a brilliant mathematician, who is working on a computer called Colossus at Bletchley in Britain, in order to crack the Lorentz encoding machines of the German forces. Ridley suggests that Turing is probably closer to the mystery of life than anyone else, as heredity is a modifiable stored program and metabolism is a universal machine. It also states that the recipe that links them is a code, an abstract message that can be embodied in a chemical, physical or even immaterial form. It also states that anything that can use the resources of the world to get copies of itself made is alive, and the most likely form for such a thing to take is a digital message.

Ridley argues that neither DNA nor protein could have existed without the other and that it is difficult to imagine how one could have come before the other. He notes that there is growing evidence that RNA, a chemical substance that links the two worlds of DNA and protein, came before proteins, and that RNA was the ancestor of both DNA and protein. The author compares RNA to ancient Greece and DNA to ancient Rome, and suggests that RNA was the precursor of DNA

"A gilded No is more satisfactory than a dry yes" - Gracian