Dopamine Nation Summary (8/10)

“Dopamine Nation” by Dr. Anna Lembke explores the role of dopamine, the neurochemical linked to pleasure, in contemporary society’s rapidly increasing addiction to everything from drugs to food and technology. The book highlights how the evolution of “limbic capitalism” or “dopamine economy” has increased accessibility and potency of a variety of substances.

Technological advancements, such as the cigarette-rolling machine, have led to the mass consumption of harmful substances like cigarettes, causing millions of deaths annually. Modern pharmaceutical-grade opioids are available in every form and are more potent than ever before. Cannabis is significantly more potent than it was in the 1960s and has diversified into a variety of edible forms. Food has also been manipulated to satisfy our modern appetite for flavors, leading to overconsumption of processed foods and increased obesity rates worldwide.

The book notes that 70% of world global deaths are due to modifiable behavioral risk factors like smoking, diet, and physical inactivity. Addiction rates are increasing globally, with drug of choice varying by country.

Lembke discusses how societal attitudes towards pain have dramatically changed over the centuries. Previously, pain was considered a necessary part of healing. Today, however, the medical community seeks to eliminate all pain, leading to the mass prescription of “feel-good” pills such as antidepressants, stimulants, and sedatives.

Furthermore, the book describes our culture’s growing inability to tolerate discomfort or boredom, with people constantly seeking distraction. This constant state of distraction can contribute to mental health problems like depression and anxiety. The book suggests embracing discomfort as an opportunity for discovery and invention.

Interestingly, studies indicate that wealthier countries have higher rates of anxiety. Physical pain is also increasing, with more people experiencing unexplained body pain.

The book explains how pleasure and pain are processed in overlapping brain regions, functioning like a balance. This balance can be tipped by substances like opioids, which initially provide relief but can lead to increased pain over time due to a phenomenon known as opioid-induced hyperalgesia. Heavy, prolonged consumption of high-dopamine substances eventually leads to a dopamine deficit state, contributing to the cycle of addiction.

Volkow examined dopamine transmission in the brains of healthy controls compared to people addicted to a variety of drugs two weeks after they stopped using. The brain images are striking. In the brain pictures of healthy controls, a kidney-bean-shaped area of the brain associated with reward and motivation lights up bright red, indicating high levels of dopamine neurotransmitter activity. In the pictures of people with addiction who stopped using two weeks prior, the same kidney-bean-shaped region of the brain contains little or no red, indicating little or no dopamine transmission.

The book discusses the works of Dr. Volkow and her team, which shows that drug abuse reduces the number of DA D2 receptors in the brain and dopamine release. This results in a decreased sensitivity of reward circuits to stimulation by natural rewards, leading to anhedonia – the inability to enjoy pleasure.

Here are some bullets that summarize the rest of the book:

• The author uses the metaphor of ‘Team Dopamine’ retiring, to explain this loss of pleasure, and shares personal experience of losing interest in reading romance novels due to overconsumption.

• Addicted patients report their drug ceasing to work, offering no high anymore. However, not taking the drug makes them miserable. This pleasure-pain balance can tilt towards pain, driving relapse even after abstinence.
• With time, our brains can reestablish a level balance of pleasure-pain, enabling us to enjoy simple rewards again.
• Not only reexposure to the drug, but also exposure to cues associated with drug use, can trigger the pleasure-pain balance.
• The author quotes colleague Rob Malenka who highlights that the measure of an animal’s addiction is how hard they work to obtain their drug. The same applies to humans.
• Dopamine release can increase due to the unpredictability of reward delivery, such as with gambling.
• The author explains the risks of high cannabis consumption and its potential effect on anxiety. High cannabis consumption may contribute to baseline anxiety, rather than treating it.
• The book discusses the increasing ubiquity of high-dopamine goods and digital devices, necessitating self-binding strategies to avoid overconsumption.
• Neuroscientists S. H. Ahmed and George Koob’s study shows that limiting the window of drug access may avoid compulsive and escalating consumption.
• Modern society has a lot more leisure time due to the mechanization of labor-intensive jobs. This has led to increased consumption of dopamine-rich activities and substances.
• The book highlights how the rapid rise of gluten-free products demonstrates market forces countering consumption control attempts.
• Certain taboo drugs have been transformed into socially acceptable commodities, often under the guise of medicine.
• The use of hallucinogens in controlled, therapeutic settings is discussed, with the goal of harnessing their properties without leading to misuse or addiction.
• The book recounts the story of Jacob, a man who took extraordinary measures to avoid inciting sexual desire and felt liberated by this self-imposed discipline.
• The link between economic hardships and substance use is highlighted, using data from the US Department of Health and Human Services.
• The book cites the movie Serenity as an example of the danger of eradicating all forms of human suffering – the population, deprived of all desires, essentially perishes.
• The author states that while medications can be lifesaving, there is a cost to medicating away every type of human suffering. An alternative path might be to embrace pain.
• The book shares an anecdote of a person who used cold-water therapy to improve mood and assist in recovery from addiction, drawing parallels with drug highs.
• The historical context of cold water bathing is discussed, from ancient Greeks advocating its health benefits to a German farmer promoting it as a cure-all treatment in the 1920s.
• Hot showers and baths have become common due to advancements in plumbing and heating, yet recently, ice-water immersion is regaining popularity. Endurance athletes, for instance, believe it enhances muscle recovery.
• The concept of the “Scottish shower” or the “James Bond shower,” involving a hot shower finished with a minute of cold water, is enjoying renewed interest.
• Wim Hof, a Dutchman known for enduring near-freezing temperatures for long periods, is a renowned figure in the ice-water immersion movement.
• Researchers at Charles University in Prague studied the effects of cold-water immersion (14 degrees Celsius) on ten men for one hour. Blood tests revealed increases in plasma dopamine and norepinephrine concentrations by 250% and 530%, respectively.
• Dopamine levels slowly increased throughout the cold bath and remained high for an hour afterward, while norepinephrine surged in the initial 30 minutes, plateaued, and then dropped to remain above baseline even two hours after the bath.
• Cold-water immersion studies in humans and animals have shown similar increases in monoamine neurotransmitters such as dopamine, norepinephrine, and serotonin – neurotransmitters that regulate mood, pleasure, motivation, appetite, sleep, and alertness.
• Extreme cold in animals promotes neuronal growth, a surprising finding as neurons typically only alter their microstructure in response to very few conditions.
• A study on hibernating ground squirrels found that at freezing temperatures, the neurons resemble spindly trees with few dendrites (branches) and microdendrites (leaves). As the squirrels warm up, the neurons show remarkable regrowth akin to the rapid neuronal plasticity observed in embryonic development.
• The book mentions Michael, who discovered the benefits of ice-cold water immersion. He noticed that enduring the initial discomfort led to prolonged feelings of pleasure. This phenomenon is attributed to the body’s natural homeostatic response to pain.
• The study cites the potential benefits of low-dose radiation exposure on the lifespan and cancer rates among Japanese citizens living outside the epicenter of the 1945 nuclear attack.
• Intermittent fasting and calorie restriction, popular for weight loss and well-being improvement, have shown lifespan extension and increased resistance to age-related diseases in rodents and monkeys. The book mentions talk show host Jimmy Kimmel, who practices intermittent fasting.
• Exercise, while initially harmful to cells, has numerous health benefits. It increases the neurotransmitters involved in positive mood regulation, contributes to the birth of new neurons, reduces the likelihood of drug use and addiction, and aids those already addicted in reducing their consumption.
• The book discusses dopamine’s critical role in motor circuits, highlighting its importance in motivation and the need to actively obtain what we desire. The sedentary lifestyle of modern society is contrasted with our evolutionary history of daily long-distance travel for food.
• The author shares a personal account of identifying a behavior to change – late-night novel reading – during a therapy session. Through self-reflection, the author realizes the importance of prioritizing family and work over personal pleasure.
• The book concludes with a call to embrace the “lessons of the balance” in the context of today’s pleasure-saturated world, advocating for abstinence, self-binding, and an acceptance of pain to reset the balance towards pleasure. This approach aims to help navigate the challenges of an overstimulated, hypermedicated society.